As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
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چکیده
منابع مشابه
Platelet amino acid levels in essential thrombocytosis.
By RALPH L. NACHMAN, HERBERT I. HoRowrrz AND RICHARD T. SILVER E SSENTIAL THROMBOCYTOSIS is a disorder of unknown etiology characterized by a marked increase in the number of circulating platelets, and max’ l)C related to the myeloproliferative diseases.1 In the course of this condition, many patients develop hemorrhagic and/or thrombotic complicalions, which may result from an abnormal number ...
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In the rat hepatocyte, whether freshly separated or in primary culture, we do not find L-glutamine entry by Systems A and ASC as seen in cells previously studied. Instead the mediated entry of glutamine appears to occur exclusively by a Na+-dependent system ("N") apparently specific to amino acid amides and L-histidine; however, a portion of asparagine uptake occurs by System A. The simplest ev...
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Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood. Here we describe a role for asparagine as an amino acid exchange factor: intracellular asparagine exchanges with extracellular amino acids. Through asparagine synthetase knockdown and altering of media asparagine concentration...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2018
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2017.12.006